Police have closed down a cannabis factory in Headley Way, Headington - the seventh raided in Oxford this year.
Officers raided the house at around 9pm last night and three people were arrested on suspicion of cultivating cannabis.
Sgt Steve Willis, who led the operation, said: "An early estimation is that there are 300 to 400 plants that were being cultivated, every room in the house was being used.
"I think this is further evidence that we take a hard-line on all types of drugs and that we take every opportunity to prevent them reaching our streets."
A 36-year-old man, a 38-year-old woman and a 15-year-old boy were arrested on suspicion of cultivation of cannabis and are currently in police custody.
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